300,000+ smiles & counting
Zero Pro is the smartest way to care for your smile.
Featuring our breakthrough botanical ingredient, BioFuse™ Oil Matrix, Zero Pro is the only toothpaste that targets and disrupts harmful oral bacteria while leaving the good stuff untouched. Keep the good, lose the bad.
Limited launch offer on now!
300,000+ smiles & counting
Zero Pro is the smartest way to care for your smile.
Our most advanced formula yet, Zero Pro is the only toothpaste that disrupts harmful oral bacteria while leaving the good stuff untouched. Keep the good, lose the bad.
Limited launch offer!
Why Zero Pro?
Zero Pro is a toothpaste like never before. The synergistic formula eliminates bad bacteria, promotes remineralization, and balances your oral environment with every brush. Zero Pro contains BioFuse™ Oil Matrix, 10% nano-hydroxyapatite, Xylitol, and natural mint flavors without any SLS, parabens, or fluoride.
Ingredients
Water (Aqua), Glycerin, Hydrated Silica, Hydroxyapatite (nHAp), Xylitol, Sorbitol, Linum Usitatissimum (Linseed) Seed Oil, Rosa Canina (Rosehip) Seed Oil, Stevia Rebaudiana Extract, Sodium Benzoate, Mentha Piperita (Peppermint) Oil, Xanthan Gum, Potassium Sorbate, Mentha Arvensis (Wild Mint) Oil, Sodium Cocoyl Glutamate, Ultramarines (CI 77007), Zinc Citrate
Directions
The ADA recommends brushing with a pea-sized amount of toothpaste twice daily. You do not need to rinse after use.
One 4 ounce tube of Zero Pro should last approximately 2-3 months.
Subscribe & Save for up to 29% off and get refills delivered automatically while earning rewards.
Benefits
Results may vary, but users report increased saliva flow, a cleaner-feeling mouth, smoother and whiter teeth within the first week of use. Over time, the BioFuse™ Oil Matrix, nHAp, and Xylitol will reduce harmful microbiome, remineralize damaged enamel, and reduce your risk of cavities.
Zero Pro Toothpaste
New!
Pro Formula
Fluoride-Free
SPECIAL OFFER
Buy 2 tubes and get a FREE box of Watermelon Lumismart.
Available while quantities last.
Choose Your Offer:
Subscribe & Save
Up to 29% Off
Easily customize your plan, your frequency, cancel or skip a single item in your delivery. You’re in control.
1 Tube
2-month supply for $0.56 per brush
25% OFF
Free Shipping
2 Tubes
4-month supply for $0.53 per brush
29% OFF
25% off on every order
Earn points towards rewards
Fast Delivery
Change, pause, or cancel
One-time purchase
$45.00
1 Tube
2-month supply for $0.75 per brush
Save
No 25% off extra discount
No rewards points
Made In USA
Free Shipping $60+
30 Day Returns
TRY A STARTER KIT
Why Zero Pro?
Zero Pro is a toothpaste like never before. The synergistic formula eliminates bad bacteria, promotes remineralization, and balances your oral environment with every brush. Zero Pro contains BioFuse™ Oil Matrix, 10% nano-hydroxyapatite, Xylitol, and natural mint flavors without any SLS, parabens, or fluoride.
Ingredients
Water (Aqua), Glycerin, Hydrated Silica, Hydroxyapatite (nHAp), Xylitol, Sorbitol, Linum Usitatissimum (Linseed) Seed Oil, Rosa Canina (Rosehip) Seed Oil, Stevia Rebaudiana Extract, Sodium Benzoate, Mentha Piperita (Peppermint) Oil, Xanthan Gum, Potassium Sorbate, Mentha Arvensis (Wild Mint) Oil, Sodium Cocoyl Glutamate, Ultramarines (CI 77007), Zinc Citrate
Directions
The ADA recommends brushing with a pea-sized amount of toothpaste twice daily. You do not need to rinse after use.
One 4 ounce tube of Zero Pro should last approximately 2-3 months.
Subscribe & Save for up to 29% off and get refills delivered automatically while earning rewards.
Benefits
Results may vary, but users report increased saliva flow, a cleaner-feeling mouth, smoother and whiter teeth within the first week of use. Over time, the BioFuse™ Oil Matrix, nHAp, and Xylitol will reduce harmful microbiome, remineralize damaged enamel, and reduce your risk of cavities.
ADVANCED TOOTHPASTE FOR HEALTHIER SMILES
BioFuse™
🦷
nHAp
🎋
Xylitol
🍃
Soft Mint
BioFuse™ Oil Matrix
Our unique botanical blend that targets harmful oral microbiome.
🦷
nHAp
A fluoride-alternative mineral that remineralizes damaged enamel.
🎋
Xylitol
A natural sweetener that fights cavities and boosts beneficial saliva flow.
🚫
No Fluoride, SLS, or Parabens
Zero Pro is free from unnecessary chemicals and foaming agents.
🌱
Stevia
A natural calorie-free sugar-free sweetener derived from plants.
🍃
Natural Mint Flavors
Wild mint and peppermint essential oils help freshen breath.
This isn't just oral care—this is supplements for your smile.
Transform Your Smile, Transform Your Health
Research supports the innovations in Zero Pro.
Oral inflammation affects your whole-body wellness, from your brain to your gut and beyond
Reducing inflammation and oral disease supports overall health and mental wellness
BioFuse™ Oil Matrix disrupts only the harmful microbiome, leaving the good stuff intact
Modern toothpastes don't treat the root causes of oral health issues.
Zero Pro gets at the real culprits.
47%
of U.S. adults age 30+ have periodontal (gum) disease caused by bacterial plaque buildup.
80%
of plaque buildup and gum inflammation is caused by 2% of the bacteria in your mouth.
The oral microbiome
(and why it matters)
The mouth hosts many bacterial species that impact whole-body systems.
1,000+ Bacterial Species Live in Your Mouth
Most are harmless, but some are harmful, causing inflammation and disease.
Oral Bacteria Travel Throughout Your Body
Bacteria from your mouth spread through saliva and your blood to travel to your gut and beyond.
BioFuse™ Oil Matrix keeps your mouth protected from the 'bad actors' of the oral microbiome while leaving the good stuff untouched.
MEET THE 'BAD ACTORS' IN ORAL HEALTH
S. mutans
THE CAVITY KING
• Causes tooth decay & cavities
• Produces enamel-destroying acid
• Creates sticky plaque
• Leads to whites spots & sensitivity
P. gingivalis
THE GUM DISEASE STAR
• Causes gum disease
• Leads to bone density loss
• Major source of bad breath
• Triggers chronic inflammation
BioFuse™ Oil Matrix selectively targets and eliminates these bad bacteria, removing the root cause of oral health issues - not just treating the symptoms.
SEE THE RESULTS OF BIOFUSE™ OIL MATRIX IN CLINICAL TESTING
Lab Assay Results
99.9% reduction in both bad bacteria during in vitro lab tests versus regular toothpaste.
In just 10 minutes of exposure, BioFuse™ Oil Matrix effectively eliminated both bad bacteria types by 99.9%.
Dr. Winter's Story
Near-complete elimination of harmful S. mutans in saliva after 8 days of brushing.
Dr. Winters tested his own saliva over 8 days while brushing with BioFuse™ Oil Matrix and saw near-complete elimination of S. mutans.
Swipe to see the results!
Clinical Trial
Clinical trial participants brushing with BioFuse™ Oil Matrix had ~50% less bad bacteria after 14 days.
Results of S. mutans in saliva compared to Placebo group who brushed with a major toothpaste brand over the same period.
Testing On Good Bacteria
BioFuse™ Oil Matrix shows selective elimination of bad bacteria, while letting the good guys recover.
Saliva samples collected before and after brushing with BioFuse™ Oil Matrix showed highly selective elimination of only bad bacteria.
WHAT YOU GET WHEN THE BAD GUYS ARE GONE
Less Cavities
Stronger Enamel
Healthier Microbiome
Lower Inflammation
Fresher Breath
Balanced pH
Bone Density Support
Whole-Body Benefits
THE FUTURE OF TOOTHPASTE
Zero Pro contains a synergistic formula of BioFuse™ Oil Matrix, 10% nHAp, and Xylitol.
OFFENSE AS DEFENSE
The Targeted Takedown
BioFuse™ Oil Matrix in Zero Pro spreads during brushing and physically destroys just harmful bacteria, not good stuff you need.
REBUILDING DEFENSES
Rebuilding Damage
While BioFuse™ provides defense, 10% nHAp is busy at work rebuilding damaged tooth enamel from the inside out.
RESTORING BALANCE
Natural Support
BioFuse™ promotes increased saliva flow, even more than Xylitol, and Zero Pro has both, helping neutralize acids, promote remineralization, and maintain a balanced oral environment.
LASTING HARMONY
Improved Wellness
Over time, brushing with Zero Pro reduces the harmful microbiome, boosts enamel and promotes a happier, healthier smile.
OFFENSE AS DEFENSE
The Targeted Takedown
BioFuse™ Oil Matrix in Zero Pro spreads during brushing and physically destroys just harmful bacteria, not good stuff you need.
REBUILDING DEFENSES
Rebuilding Damage
While BioFuse™ provides defense, 10% nHAp is busy at work rebuilding damaged tooth enamel from the inside out.
RESTORING BALANCE
Natural Support
BioFuse™ promotes increased saliva flow, even more than Xylitol, and Zero Pro has both, helping neutralize acids, promote remineralization, and maintain a balanced oral environment.
LASTING HARMONY
Improved Wellness
Over time, brushing with Zero Pro reduces the harmful microbiome, boosts enamel and promotes a happier, healthier smile.
This isn't just oral care—this is supplements for your smile.
Us Vs. Them
Not overhyped or overpriced. Just comprehensive smile care made for everyone.
Clinically-proven ingredients
BioFuse™ Oil Matrix
10% nano-Hydroxyapatite
No Fluoride, No SLS, No Parabens
Safe if swallowed
Reduces sensitivity
Drugstore brands
Natural toothpastes
Demand more for your mouth.
We know there's a lot of choices in oral care out there. But we wanted to bring real innovation and purpose into an industry plagued by gimmicks. Here's how Something Nice is putting the care back into smile care.
Created by a real orthodontist
Science-backed, no-gimmick formulas
Solves real-world
oral care problems
Designed to give back to others
Formulated by a dentist, made for you
After seeing the oral care industry stop innovating and continue to push centuries-old formulas, Dr. Winters decided it was time for some real change. With a modern formula that uses biomimetic 10% nHAP to rebuild enamel and breakthrough proprietary BioFuse Oil Matrix™ to protect your microbiome, Zero Pro is the only toothpaste you'll ever need.
Read Our Story
Traditional oral care built the foundation.
We're building the future.
HERE TO HELP
Have a question?
What is BioFuse Oil Matrix™ and how does it work?
BioFuse™ Oil Matrix is our advanced botanical blend which helps disrupt harmful oral microbiome while leaving the good stuff untouched. Formulated alongside clinical researchers, this botanical blend selectively targets cavity and periodontal disease-causing bacteria, S. mutans and P. gingivalis, and physically destroys the integrity of their cell walls (imagine poking holes in a water-balloon), effectively killing them.
Why doesn't Zero Pro Toothpaste foam up and why does it feel so watery when I'm brushing?
It might feel strange, but these are good things! Zero Pro is made without chemical foaming agents, like SLS, which are commonly found in toothpastes (and soaps & shampoos). You might associate foam with cleaning power, but it doesn't actually provide the boost you think it does. As well, the combination of BioFuse™ Oil Matrix and Xylitol promote a big increase in saliva flow. This has dual benefits of spreading the active ingredients (like a mouthwash), and helping balance the pH of your mouth. It may take some getting used to, but trust us, the results are worth it.
What makes nano-hydroxyapatite different from fluoride?
Nano-hydroxyapatite (nHAp) is a biocompatible mineral that's identical to what your teeth are naturally made of. Originally developed by NASA to help astronauts with bone density loss, it works to directly rebuild tooth enamel, whereas fluoride just helps your teeth absorb more minerals. At a concentration of 10% (which Zero Pro has), nHAp has been shown to be just as effective as fluoride in preventing cavities while reducing sensitivity.
Why 10% nano-hydroxyapatite—does the concentration matter?
Research indicates that a 10% concentration, nano-sized hydroxyapatite effectively penetrates enamel tubules and promotes remineralization. Lower concentrations may not provide sufficient coverage of tooth surfaces, while higher concentrations don't show additional benefits. Many brands claim to have nano-hydroxyapatite in their toothpaste without ever disclosing the concentration, which is often 3X lower than the recommended dose.
How does nano-hydroxyapatite compare to regular hydroxyapatite?
The nano-sized particles in Zero Pro are significantly smaller than non-nano hydroxyapatite particles. This smaller size allows them to penetrate deeper into microscopic enamel structures and dentinal tubules, providing better coverage and more effective remineralization.
Is there any concern of bacterial resistance if I stop use of Zero Pro?
We understand this concern, and the short answer is no. The advanced answer is that BioFuse™ uses LNP (lipid nano particle) technology and works by mechanically disturbing the cell wall/phospholipid bilayer of the bacteria. Because it targets in this physical way, instead of disrupting cellular processes or mechanisms like regular antibiotics, the risk of resistance is very low.
Can I switch between regular Zero and Zero Pro?
Yep, there aren't any issues with switching between regular Zero and Zero Pro, if you want to alternate or use the Pro formula off and on. They have very similar ingredients, with the key difference being the targeted bactericidal action of BioFuse™ in Zero Pro.
Is Zero Pro safe for kids who might swallow a bit of toothpaste?
Yes! Zero Pro is completely safe if accidentally swallowed, making it ideal for all ages and anyone who prefers a fluoride-free option. However, we recommend supervising children under the age of 12 during brushing. If excessive amounts are ingested, consult a medical professional.
When can I expect to see results for sensitivity?
Most users will experience a noticeable reduction in sensitivity within 1-2 weeks of regular use. For best results, use Zero Pro twice daily and avoid rinsing immediately after brushing.
How many shades lighter will my teeth be after using Zero Pro Toothpaste?
Everyone's smile is unique, and whitening results can vary based on your starting point, but nano-hydroxyapatite helps to fill surface imperfections in the enamel to a create a smoother, more vibrant tooth surface. This can mean your teeth benefit from natural optical whitening up to 2 shades in 1-2 weeks of brushing.
Complete Your Routine
300,000 HAPPY SMILES
Join Thousands Choosing Fluoride-Free without Sacrificing Clean
Exceeded my expectations
I was skeptical about fluoride-free toothpaste but this has exceeded my expectations. My sensitivity has decreased significantly and my teeth look noticeably whiter. The taste is great and it doesn't leave that weird aftertaste. Worth every penny.
Michael D.
Amazing fluoride-free option
This toothpaste is amazing! My teeth feel so clean and smooth after brushing. I love that it's fluoride-free but still gives me that fresh, clean feeling. The nano-hydroxyapatite really works - my teeth feel stronger and look whiter after just a few weeks of use.
Sarah K.
Pure taste formula is incredible
Best toothpaste I've ever used! The pure taste formula is incredible - I can drink orange juice right after brushing with no weird taste. My dentist noticed how much cleaner my teeth were at my last visit. This stuff really works.
Lisa M.
Testimonials featured in videos or other promotional materials may include individuals who have received compensation, free product, or other incentives.
