Discover the science behind BioFuse™ Oil Matrix
BioFuse™ is a new approach to oral care designed to target the key drivers of cavities and periodontal disease.
Discover the science behind BioFuse™ Oil Matrix
BioFuse™ is a new approach designed to disrupt harmful oral bacteria, the key drivers of oral disease.
THE TRUTH NO ONE TALKS ABOUT
You started life without harmful oral bacteria.
Babies are born without harmful oral bacteria. That means cavities and gum disease aren't even possible. Then the world got involved and you were passed a bacterial community you've been living with ever since.
THE TRUTH NO ONE TALKS ABOUT
You started life without harmful oral bacteria.
Babies are born without harmful oral bacteria. That means cavities and gum disease aren't even possible. Then the world got involved and you were passed a bacterial community you've been living with ever since.
THE TRANSMISSION PROBLEM
Your bacterial profile was inherited, not chosen. Every moment of close contact was passing bacteria to you, the good and the bad. Until now, you'd have them for life.
0-6 MONTHS
6-12 MONTHS
1-5 YEARS
YEARS 5+
Parents & Family
The primary source of bacterial transmission is the mother, but early exposure from family occurs through kissing, shared utensils and food.
Food, Pets & Environment
Solid food introduction creates the first major environmental exposure. Pets, soil, and shared household surfaces start contributing meaningfully.
Friends & Connections
Cavity-causing bacteria transmission peaks during this window through daycare, shared toys, shared food, and close-contact play with other children.
Lifestyle Factors
Bacterial profile is relatively stable. Disruptions can shift it temporarily but the foundational bacterial community tends to persist into adulthood.
0-6 MONTHS
Parents & Family
The primary source of bacterial transmission is the mother, but early exposure from family occurs through kissing, shared utensils and food.
6-12 MONTHS
Food, Pets & Environment
Solid food introduction creates the first major environmental exposure. Pets, soil, and shared household surfaces start contributing meaningfully.
1-5 YEARS
Friends & Connections
Cavity-causing bacteria transmission peaks during this window through daycare, shared toys, shared food, and close-contact play with other children.
YEARS 5+
Lifestyle Factors
Bacterial profile is relatively stable. Disruptions can shift it temporarily but the foundational bacterial community tends to persist into adulthood.
THE ROOT CAUSE OF ISSUES
The two bacteria working against your smile.
S. mutans
Cavity-causing bacteria
Causes cavities & decay
May require fillings or root canals
Creates sticky plaque
Builds up and hardens on tooth
Produces enamel-destroying acid
Sensitivity and white spots
P. gingivalis
Periodontal disease-causing bacteria
Causes gum disease
Breaks down gum tissue
Leads to bone density loss
Can lead to tooth loss
Main source of bad breath
Not even mouthwash can fix
BIOFUSE™
Actiavted Nanolipid Technology
Traditional oral care doesn't address the root cause—BioFuse™ does.
Harmful bacteria ELIMINATED
BioFuse™ targets and eliminates the two most common harmful bacteria that cause cavities and periodontal disease by physically disrupting their cell walls.
GOOD BACTERIA PRESERVED
Beneficial bacterial strains that your mouth needs are left untouched, shifting your oral microbiome to a healthier balance.
BIOFUSE™
Decreased
harmful bacteria by half in just 2 weeks°
48%
99%
Selectively eliminated
almost all harmful bacteria in 8 days†
°S. mutans saliva levels from human clinical trial
†S. mutans and P. gingivalis growth from in vitro saliva tests
Eliminates harmful bacteria
BioFuse™ targets and eliminates the two most common harmful bacteria that cause cavities and periodontal disease by physically disrupting their cell walls.
GOOD BACTERIA PRESERVED
The mechanism of BioFuse™ is able to only target the harmful bacteria so beneficial bacteria you need are left to thrive.
The data
Optimal oral health begins at the bacterial level
Lab Assay Results
-99.9%
Near complete elimination of harmful bacteria within 10 minutes.
See Study Details
Dr. Winter's Story
8 days
Dr. Winter's significantly reduced his S. mutans in 8 days.
See Study Details
Testing on Good Bacteria
Treated samples showed normal recovery of good bacteria.
See Study Details
Clinical Trial
-48%
Harmful bacteria were reduced by half in just two weeks.
See Study Details
Lab Assay Results
Lab Assay Results
99.9% reduction in both bad bacteria during in vitro lab tests versus regular toothpaste.
In just 10 minutes of exposure, BioFuse™ Oil Matrix effectively eliminated both bad bacteria types by 99.9%.
Methodology
Multi-well plates containing dilute bacterial cultures in saliva
Protocol
Wells were treated with buffer solution, placebo toothpaste, and toothpaste with BioFuse™ for 10 minutes and then measured for live bacteria
Objective
Investigate the efficacy of BioFuse™ in reducing specific cavity and periodontal disease bacteria in saliva
We are committed to conducting rigorous scientific research and sharing it with our customers and are working to publish our research with the help of our trust technical science and testing partners.
Dr. Winter's Story
Dr. Winter's Story
Near-complete elimination of harmful S. mutans in saliva after 8 days of brushing.
Dr. Winters tested his own saliva over 8 days while brushing with BioFuse™ Oil Matrix and saw near-complete elimination of S. mutans.
Methodology
Participants
Dr. Ben Winters provided his own saliva samples for culture plating over an 8 day period
Protocol
Saliva samples were taken over 8 days whilte brushing with BioFuse™ toothpaste. Samples were plated on Mutans-sanguis agar + Potassium Tellurite and Bacitracin† to monitor growth of S. mutans.
†grows only Strep mutans
Objective
Investigate the efficacy of BioFuse™ in selectively eliminating cavity-causing bacteria in a saliva sample.
We are committed to conducting rigorous scientific research and sharing it with our customers. We are actively working with our technical team of scientists to publish our research.
Clinical Trial
Clinical Trial
Clinical trial participants brushing with BioFuse™ Oil Matrix had ~50% less bad bacteria after 14 days.
Results of S. mutans in saliva compared to Placebo group who brushed with a major toothpaste brand over the same period.
Methodology
Participants
60-patient healthy adult subjects ranging in age
Protocol
Placebo-controlled double-blind randomized trial — the 'Gold Standard'
Objective
Investigate the efficacy of BioFuse™ in eliminating harmful oral bacteria in average adults
We are committed to conducting rigorous scientific research and sharing it with our customers. We are actively working with our technical team of scientists to publish our research.
Testing On Good Bacteria
Testing On Good Bacteria
BioFuse™ Oil Matrix shows selective elimination of bad bacteria, while letting the good guys recover.
Saliva samples collected before and after brushing with BioFuse™ Oil Matrix vs. standard toothpaste showed selective elimination of only bad bacteria.
Methodology
Lab Assay
96-well plates of saliva samples supplemented with dilute bacterial culture
Protocol
Saliva samples from before and after brushing with BioFuse™ toothpaste were plated and treated with diluted bacteria culture
Objective
Investigate the efficacy of Mitopure on mitophagy in otherwise healthy middle-aged, overweight and inactive individuals
We are committed to conducting rigorous scientific research and sharing it with our customers, which is why we publish our work in open access, peer-reviewed journals. Read the full results of the study in Cell Reports Medicine.
Put BioFuse™ to work.
Zero Pro and Halo Gum are the only products in the world with BioFuse™ Oil Matrix.
BROWSE ALL PRODUCTS
“By selectively disrupting harmful bacteria without affecting beneficial strains, we can prevent the oral microbiome from becoming imbalanced and fight a root cause of decay, supporting your mouth's natural defenses and promoting long-term oral health."
— Dr. Ben Winters,
DDS/MS, Founder & Chief Innovation Officer