Discover the science behind BioFuse™ Oil Matrix
BioFuse™ is a new approach to oral care designed to target the key drivers of cavities and periodontal disease.
Discover the science behind BioFuse™ Oil Matrix
BioFuse™ is a new approach designed to disrupt harmful oral bacteria, the key drivers of oral disease.
THE TRUTH NO ONE TALKS ABOUT
You started life without harmful oral bacteria.
Babies are born without harmful oral bacteria. That means cavities and gum disease aren't even possible. Then the world got involved and you were passed a bacterial community you've been living with ever since.
THE TRANSMISSION PROBLEM
Your bacterial profile was inherited, not chosen. Every moment of close contact was passing bacteria to you, the good and the bad. Until now, you'd have them for life.
OFFENSE AS DEFENSE
The Targeted Takedown
BioFuse™ Oil Matrix in Zero Pro spreads during brushing and physically destroys just harmful bacteria, not good stuff you need.
REBUILDING DEFENSES
Rebuilding Damage
While BioFuse™ provides defense, 10% nHAp is busy at work rebuilding damaged tooth enamel from the inside out.
RESTORING BALANCE
Natural Support
BioFuse™ promotes increased saliva flow, even more than Xylitol, and Zero Pro has both, helping neutralize acids, promote remineralization, and maintain a balanced oral environment.
LASTING HARMONY
Improved Wellness
Over time, brushing with Zero Pro reduces the harmful microbiome, boosts enamel and promotes a happier, healthier smile.
0-6 MONTHS
Parents & Family
The primary source of bacterial transmission is the mother, but early exposure from family occurs through kissing, shared utensils and food.
6-12 MONTHS
Food, Pets & Environment
Solid food introduction creates the first major environmental exposure. Pets, soil, and shared household surfaces start contributing meaningfully.
1-5 YEARS
Friends & Connections
Cavity-causing bacteria transmission peaks during this window through daycare, shared toys, shared food, and close-contact play with other children.
YEARS 5+
Lifestyle Factors
Bacterial profile is relatively stable. Disruptions can shift it temporarily but the foundational bacterial community tends to persist into adulthood.
THE ROOT CAUSE OF ISSUES
The two bacteria working against your smile.
S. mutans
Cavity-causing bacteria
Causes cavities & decay
May require fillings or root canals
Creates sticky plaque
Builds up and hardens on tooth
Produces enamel-destroying acid
Sensitivity and white spots
P. gingivalis
Periodontal disease-causing bacteria
Causes gum disease
Breaks down gum tissue
Leads to bone density loss
Can lead to tooth loss
Main source of bad breath
Not even mouthwash can fix
BIOFUSE™ Nanolipid Technology
Traditional oral care doesn't address the root cause—BioFuse™ does.
Harmful bacteria ELIMINATED
BioFuse™ targets and eliminates the two most common harmful bacteria that cause cavities and periodontal disease by physically disrupting their cell walls.
GOOD BACTERIA PRESERVED
Beneficial bacterial strains that your mouth needs are left untouched, shifting your oral microbiome to a healthier balance.
BIOFUSE™
Decreases
harmful bacteria°
48%
°S. mutans
Eliminates harmful bacteria
BioFuse™ targets and eliminates the two most common harmful bacteria that cause cavities and periodontal disease by physically disrupting their cell walls.
GOOD BACTERIA PRESERVED
The mechanism of BioFuse™ is able to only target the harmful bacteria so beneficial bacteria you need are left to thrive.
The data
Optimal oral health begins at the bacterial level
Lab Assay Results
-99.9%
Near complete elimination of harmful bacteria within 10 minutes.
See Study Details
Dr. Winter's Story
8 days
Dr. Winter's significantly reduced his S. mutans in 8 days.
See Study Details
Testing on Good Bacteria
Treated samples showed normal recovery of good bacteria.
See Study Details
Clinical Trial
-48%
Harmful bacteria were reduced by half in just two weeks.
See Study Details
Lab Assay Results
Lab Assay Results
99.9% reduction in both bad bacteria during in vitro lab tests versus regular toothpaste.
In just 10 minutes of exposure, BioFuse™ Oil Matrix effectively eliminated both bad bacteria types by 99.9%.
Methodology
Participants
90 healthy, overweight, middle aged subjects aged 40 to 65 years
Protocol
Randomized, double-blind, placebo-controlled — the “gold standard” in studies
Objective
Investigate the efficacy of Mitopure on mitophagy in otherwise healthy middle-aged, overweight and inactive individuals
We are committed to conducting rigorous scientific research and sharing it with our customers, which is why we publish our work in open access, peer-reviewed journals. Read the full results of the study in Cell Reports Medicine.
Dr. Winter's Story
Dr. Winter's Story
Near-complete elimination of harmful S. mutans in saliva after 8 days of brushing.
Dr. Winters tested his own saliva over 8 days while brushing with BioFuse™ Oil Matrix and saw near-complete elimination of S. mutans.
Methodology
Participants
90 healthy, overweight, middle aged subjects aged 40 to 65 years
Protocol
Randomized, double-blind, placebo-controlled — the “gold standard” in studies
Objective
Investigate the efficacy of Mitopure on mitophagy in otherwise healthy middle-aged, overweight and inactive individuals
We are committed to conducting rigorous scientific research and sharing it with our customers, which is why we publish our work in open access, peer-reviewed journals. Read the full results of the study in Cell Reports Medicine.
Clinical Trial
Clinical Trial
Clinical trial participants brushing with BioFuse™ Oil Matrix had ~50% less bad bacteria after 14 days.
Results of S. mutans in saliva compared to Placebo group who brushed with a major toothpaste brand over the same period.
Methodology
Participants
90 healthy, overweight, middle aged subjects aged 40 to 65 years
Protocol
Randomized, double-blind, placebo-controlled — the “gold standard” in studies
Objective
Investigate the efficacy of Mitopure on mitophagy in otherwise healthy middle-aged, overweight and inactive individuals
We are committed to conducting rigorous scientific research and sharing it with our customers, which is why we publish our work in open access, peer-reviewed journals. Read the full results of the study in Cell Reports Medicine.
Testing On Good Bacteria
Testing On Good Bacteria
BioFuse™ Oil Matrix shows selective elimination of bad bacteria, while letting the good guys recover.
Saliva samples collected before and after brushing with BioFuse™ Oil Matrix vs. standard toothpaste showed selective elimination of only bad bacteria.
Methodology
Participants
90 healthy, overweight, middle aged subjects aged 40 to 65 years
Protocol
Randomized, double-blind, placebo-controlled — the “gold standard” in studies
Objective
Investigate the efficacy of Mitopure on mitophagy in otherwise healthy middle-aged, overweight and inactive individuals
We are committed to conducting rigorous scientific research and sharing it with our customers, which is why we publish our work in open access, peer-reviewed journals. Read the full results of the study in Cell Reports Medicine.
EXPERIENCE THE BENEFITS
Life-changing oral care, built with your microbiome in mind.
Experience the difference BioFuse™ makes for your smile, your health, and your life.
Explore Products
Put BioFuse™ to work.
Zero Pro and Halo Gum are the only products in the world with BioFuse™ Oil Matrix.
BROWSE ALL PRODUCTS
“By selectively disrupting harmful bacteria without affecting beneficial strains, we can prevent the oral microbiome from becoming imbalanced and fight a root cause of decay, supporting your mouth's natural defenses and promoting long-term oral health."
— Dr. Ben Winters,
DDS/MS, Founder & Chief Innovation Officer